FKBP5_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: FKBP5 , AIG6, FKBP51
Protein names and data: FKBP5_HUMAN , Peptidyl-prolyl cis-trans isomerase FKBP5; PPIase FKBP5; 5.2.1.8 , 51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase Lenght: 457 a.a.
Mass: 51212 Da
fasta formatted sequence
Function: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Widely expressed, enriched in testis compared to other tissues.

Database cross-references

UniProt: Q13451
Ensembl: ENST00000357266
Ensembl: ENST00000536438
Ensembl: ENST00000539068
Ensembl: ENST00000542713
MIM: 602623
neXtProt: NX_Q13451
Antibodypedia: Q13451 (may not find the protein thus also not any antibody)
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