FNTA_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: FNTA
Protein names and data: FNTA_HUMAN , Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; 2.5.1.58; 2.5.1.59 , CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha Lenght: 379 a.a.
Mass: 44409 Da
fasta formatted sequence
Function: Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
Catalytic activity: Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate. Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Database cross-references

UniProt: P49354
Ensembl: ENST00000302279
Ensembl: ENST00000342116
MIM: 134635
neXtProt: NX_P49354
Antibodypedia: P49354 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.