G3BP1_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: G3BP1 , G3BP
Protein names and data: G3BP1_HUMAN , Ras GTPase-activating protein-binding protein 1; G3BP-1; 3.6.4.12; 3.6.4.13 , ATP-dependent DNA helicase VIII; hDH VIII; GAP SH3 domain-binding protein 1 Lenght: 466 a.a.
Mass: 52164 Da
fasta formatted sequence
Function: May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.
Catalytic activity: ATP + H(2)O = ADP + phosphate.
Cellular location: Cytoplasm. Cytoplasm, cytosol. Cell membrane. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By similarity). Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS.
Tissue specificity: Ubiquitous.

Database cross-references

UniProt: Q13283
Ensembl: ENST00000356245
Ensembl: ENST00000394123
MIM: 608431
neXtProt: NX_Q13283
Antibodypedia: Q13283 (may not find the protein thus also not any antibody)
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