GAK_HUMAN

Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: GAK
Protein names and data: GAK_HUMAN , Cyclin-G-associated kinase; 2.7.11.1 Lenght: 1311 a.a.
Mass: 143191 Da
fasta formatted sequence

Function: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cellular location: Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Cell junction, focal adhesion (Probable). Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
Tissue specificity: Ubiquitous. Highest in testis.

Genetic variants

Database cross-references

UniProt: O14976
Ensembl: ENST00000314167
MIM: 602052
neXtProt: NX_O14976
Antibodypedia: O14976 (may not find the protein thus also not any antibody)
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