GAPD1_HUMAN

Source: hRBCD ; ID: IPI00292753
PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: GAPVD1 , GAPEX5, KIAA1521, RAP6
Protein names and data: GAPD1_HUMAN , GTPase-activating protein and VPS9 domain-containing protein 1 , GAPex-5; Rab5-activating protein 6 Lenght: 1478 a.a.
Mass: 164980 Da
fasta formatted sequence
Function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.
Cellular location: Membrane; Peripheral membrane protein. Endosome. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.

Database cross-references

UniProt: Q14C86
Ensembl: ENST00000265956
Ensembl: ENST00000297933
Ensembl: ENST00000312123
Ensembl: ENST00000394104
Ensembl: ENST00000394105
Ensembl: ENST00000470056
Ensembl: ENST00000495955
MIM: 611714
neXtProt: NX_Q14C86
Antibodypedia: Q14C86 (may not find the protein thus also not any antibody)
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