GBRL1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: GABARAPL1 , GEC1
Protein names and data: GBRL1_HUMAN , Gamma-aminobutyric acid receptor-associated protein-like 1 , Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1; GEC-1; Flags: Precursor Lenght: 117 a.a.
Mass: 14044 Da
fasta formatted sequence
Function: Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Cellular location: Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Lipid-anchor. Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Cytoplasmic vesicle, autophagosome.
Tissue specificity: Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta.

Database cross-references

UniProt: Q9H0R8
Ensembl: ENST00000266458
Ensembl: ENST00000421801
Ensembl: ENST00000543602
Ensembl: ENST00000545887
MIM: 607420
neXtProt: NX_Q9H0R8
Antibodypedia: Q9H0R8 (may not find the protein thus also not any antibody)
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