GBRL2_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: GABARAPL2 , FLC3A, GEF2
Protein names and data: GBRL2_HUMAN , Gamma-aminobutyric acid receptor-associated protein-like 2 , GABA(A) receptor-associated protein-like 2; Ganglioside expression factor 2; GEF-2; General protein transport factor p16; Golgi-associated ATPase enhancer of 16 kDa; GATE-16; MAP1 light chain 3-related protein; Flags: Precursor Lenght: 117 a.a.
Mass: 13667 Da
fasta formatted sequence
Function: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Cellular location: Golgi apparatus (By similarity). Cytoplasmic vesicle, autophagosome.
Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.

Genetic variants

Database cross-references

UniProt: P60520
Ensembl: ENST00000037243
MIM: 607452
neXtProt: NX_P60520
Antibodypedia: P60520 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.