Source: hRBCD ; ID: IPI00298800
BGMUT ; ID: mns
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: GYPA , GPA
Protein names and data: GLPA_HUMAN , Glycophorin-A , MN sialoglycoprotein; PAS-2; Sialoglycoprotein alpha; CD235a; Flags: Precursor Lenght: 150 a.a.
Mass: 16331 Da
fasta formatted sequence

Function: Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
Cellular location: Cell membrane; Single-pass type I membrane protein. Note=Appears to be colocalized with SLC4A1.

Genetic variants

Along with GYPB, GYPA is responsible for the MNS blood group system. The molecular basis of the GPA M/N bloodgroup antigen is a variation at positions 20 and 24. Ser-20 and Gly-24 correspond to M (shown); 'Leu-20' and 'Glu-24' correspond to N. GYPA polymorphisms are involved in resistance to malaria [MIM:611162].

Database cross-references

UniProt: P02724
Ensembl: ENST00000324022
Ensembl: ENST00000360771
Ensembl: ENST00000535709
MIM: 111300
MIM: 611162
neXtProt: NX_P02724
Antibodypedia: P02724 (may not find the protein thus also not any antibody)
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