RBCC Red Blood Cell Collection

GLPB_HUMAN

Source: PM23856902
BGMUT ; ID: mns
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)
Gene names: GYPB , GPB
Protein names and data: GLPB_HUMAN , Glycophorin-B , PAS-3; SS-active sialoglycoprotein; Sialoglycoprotein delta; CD235b; Flags: Precursor Lenght: 91 a.a.
Mass: 9782 Da
fasta formatted sequence
Function: This protein is a minor sialoglycoprotein in erythrocyte membranes.
Cellular location: Cell membrane; Single-pass type I membrane protein.

Genetic variants

Along with GYPA, GYPB is responsible for the MNS blood group system. The molecular basis of the S/s blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 and Met-48 to S=MNS3.

22 - 22 T -> S (in M(v) antigen). VAR_047948
48 - 48 T -> M (in S antigen and Mit antigen; dbSNP:rs7683365). VAR_003192 7683365
54 - 54 R -> H (in Mit antigen). VAR_047949
58 - 58 P -> R (in s(D) antigen). VAR_047950
84 - 84 S -> T (in dbSNP:rs1132783). VAR_030785 1132783

Database cross-references

UniProt: P06028
Ensembl: ENST00000283126
Ensembl: ENST00000502664
Ensembl: ENST00000513128
MIM: 111740
neXtProt: NX_P06028
Antibodypedia: P06028 (may not find the protein thus also not any antibody)
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