Source: hRBCD ; ID: IPI00026299
BGMUT ; ID: gerbich
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: GYPC , GLPC, GPC
Protein names and data: GLPC_HUMAN , Glycophorin-C , Glycoconnectin; Glycophorin-D; GPD; Glycoprotein beta; PAS-2'; Sialoglycoprotein D; CD236 Lenght: 128 a.a.
Mass: 13811 Da
fasta formatted sequence

Function: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
Cellular location: Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1.
Tissue specificity: Glycophorin-C is expressed in erythrocytes. Glycophorin-D is ubiquitous.

Genetic variants

GYPC is responsible for the Gerbich blood group system. Deletion of exon 3 in GYPC changes the serologic phenotype of the Gerbich blood group system, resulting in Ge negativity. Ge negative individuals are protected against severe malaria due to erythrocytes resistance to Plasmodium falciparum invasion [MIM:611162].

Database cross-references

UniProt: P04921
Ensembl: ENST00000259254
Ensembl: ENST00000356887
Ensembl: ENST00000409836
MIM: 110750
MIM: 611162
neXtProt: NX_P04921
Antibodypedia: P04921 (may not find the protein thus also not any antibody)
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