GLRX3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: GLRX3 , PICOT, TXNL2 , HUSSY-22
Protein names and data: GLRX3_HUMAN , Glutaredoxin-3 , PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2 Lenght: 335 a.a.
Mass: 37432 Da
fasta formatted sequence
Function: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Cellular location: Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity).
Tissue specificity: Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.

Genetic variants

Database cross-references

UniProt: O76003
Ensembl: ENST00000331244
Ensembl: ENST00000368644
Ensembl: ENST00000481034
MIM: 612754
neXtProt: NX_O76003
Antibodypedia: O76003 (may not find the protein thus also not any antibody)
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