GMPR2_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: GMPR2
Protein names and data: GMPR2_HUMAN , GMP reductase 2; 1.7.1.7 , Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2 Lenght: 348 a.a.
Mass: 37874 Da
fasta formatted sequence
Function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
Catalytic activity: Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.
Tissue specificity: Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.

Genetic variants

Database cross-references

UniProt: Q9P2T1
Ensembl: ENST00000355299
Ensembl: ENST00000399440
Ensembl: ENST00000420554
Ensembl: ENST00000559836
MIM: 610781
neXtProt: NX_Q9P2T1
Antibodypedia: Q9P2T1 (may not find the protein thus also not any antibody)
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