GNAI2_HUMAN

Source: PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: GNAI2 , GNAI2B
Protein names and data: GNAI2_HUMAN , Guanine nucleotide-binding protein G(i) subunit alpha-2 , Adenylate cyclase-inhibiting G alpha protein Lenght: 355 a.a.
Mass: 40451 Da
fasta formatted sequence
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.
Cellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.

Database cross-references

UniProt: P04899
Ensembl: ENST00000266027
Ensembl: ENST00000313601
Ensembl: ENST00000451956
Ensembl: ENST00000574925
Ensembl: ENST00000576852
MIM: 139360
neXtProt: NX_P04899
Antibodypedia: P04899 (may not find the protein thus also not any antibody)
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