GOLP3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: GOLPH3 , GPP34
Protein names and data: GOLP3_HUMAN , Golgi phosphoprotein 3 , Coat protein GPP34; Mitochondrial DNA absence factor; MIDAS Lenght: 298 a.a.
Mass: 33811 Da
fasta formatted sequence
Function: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.
Cellular location: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Cell membrane (By similarity). Endosome (By similarity). Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes (Probable).
Tissue specificity: Detected in muscle fibers of patients with mitochondrial diseases; not detected in normal muscle fibers.

Database cross-references

UniProt: Q9H4A6
Ensembl: ENST00000265070
MIM: 612207
neXtProt: NX_Q9H4A6
Antibodypedia: Q9H4A6 (may not find the protein thus also not any antibody)
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