GPAT4_HUMAN

Source: PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: AGPAT6 , GPAT4 , UNQ551/PRO1108
Protein names and data: GPAT4_HUMAN , Glycerol-3-phosphate acyltransferase 4; GPAT4; 2.3.1.15 , 1-acylglycerol-3-phosphate O-acyltransferase 6; 1-AGP acyltransferase 6; 1-AGPAT 6; Acyl-CoA:glycerol-3-phosphate acyltransferase 4; Lysophosphatidic acid acyltransferase zeta; LPAAT-zeta; Flags: Precursor Lenght: 456 a.a.
Mass: 52071 Da
fasta formatted sequence
Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs.
Catalytic activity: Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate.
Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue specificity: Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung.

Database cross-references

UniProt: Q86UL3
Ensembl: ENST00000396987
MIM: 608143
neXtProt: NX_Q86UL3
Antibodypedia: Q86UL3 (may not find the protein thus also not any antibody)
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