GPX4_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: GPX4
Protein names and data: GPX4_HUMAN , Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; PHGPx; 1.11.1.12 , Glutathione peroxidase 4; GPx-4; GSHPx-4; Flags: Precursor Lenght: 197 a.a.
Mass: 22175 Da
fasta formatted sequence
Function: Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
Catalytic activity: 2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O.
Cellular location: Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm.
Tissue specificity: Present primarily in testis.

Genetic variants

Database cross-references

UniProt: P36969
Ensembl: ENST00000354171
MIM: 138322
neXtProt: NX_P36969
Antibodypedia: P36969 (may not find the protein thus also not any antibody)
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