GRK6_HUMAN

Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: GRK6 , GPRK6
Protein names and data: GRK6_HUMAN , G protein-coupled receptor kinase 6; 2.7.11.16 , G protein-coupled receptor kinase GRK6 Lenght: 576 a.a.
Mass: 65991 Da
fasta formatted sequence
Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Catalytic activity: ATP + [G-protein-coupled receptor] = ADP + [G- protein-coupled receptor] phosphate.
Cellular location: Membrane; Lipid-anchor.
Tissue specificity: Widely expressed.

Genetic variants

Database cross-references

UniProt: P43250
Ensembl: ENST00000355472
Ensembl: ENST00000355958
Ensembl: ENST00000528793
MIM: 600869
neXtProt: NX_P43250
Antibodypedia: P43250 (may not find the protein thus also not any antibody)
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