GSK3A_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: GSK3A
Protein names and data: GSK3A_HUMAN , Glycogen synthase kinase-3 alpha; GSK-3 alpha; 2.7.11.26 , Serine/threonine-protein kinase GSK3A; 2.7.11.1 Lenght: 483 a.a.
Mass: 50981 Da
fasta formatted sequence
Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate. ATP + a protein = ADP + a phosphoprotein.

Genetic variants

Database cross-references

UniProt: P49840
Ensembl: ENST00000222330
Ensembl: ENST00000453535
MIM: 606784
neXtProt: NX_P49840
Antibodypedia: P49840 (may not find the protein thus also not any antibody)
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