GSTO1_HUMAN

Source: hRBCD ; ID: IPI00019755
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: GSTO1 , GSTTLP28
Protein names and data: GSTO1_HUMAN , Glutathione S-transferase omega-1; GSTO-1; 2.5.1.18 , Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; 1.8.5.1; Monomethylarsonic acid reductase; MMA(V) reductase; 1.20.4.2; S-(Phenacyl)glutathione reductase; SPG-R Lenght: 241 a.a.
Mass: 27566 Da
fasta formatted sequence
Function: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Catalytic activity: RX + glutathione = HX + R-S-glutathione. 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate. Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
Cellular location: Cytoplasm, cytosol.
Tissue specificity: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.

Genetic variants

Database cross-references

UniProt: P78417
Ensembl: ENST00000369710
Ensembl: ENST00000369713
Ensembl: ENST00000539281
MIM: 605482
neXtProt: NX_P78417
Antibodypedia: P78417 (may not find the protein thus also not any antibody)
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