GSTT1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: GSTT1
Protein names and data: GSTT1_HUMAN , Glutathione S-transferase theta-1; 2.5.1.18 , GST class-theta-1; Glutathione transferase T1-1 Lenght: 240 a.a.
Mass: 27335 Da
fasta formatted sequence
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
Catalytic activity: RX + glutathione = HX + R-S-glutathione.
Cellular location: Cytoplasm.
Tissue specificity: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.

Genetic variants

The GSTT1 gene is absent from 38% of the population. The presence or absence of the GSTT1 gene is coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes respectively. The GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane.

Database cross-references

UniProt: P30711
Ensembl: ENST00000248935
MIM: 600436
neXtProt: NX_P30711
Antibodypedia: P30711 (may not find the protein thus also not any antibody)
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