Source: BSc_CH
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: H3F3A , H3.3B , PP781
Protein names and data: H33_HUMAN , Histone H3.3 Lenght: 136 a.a.
Mass: 15328 Da
fasta formatted sequence

Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular location: Nucleus. Chromosome.

Database cross-references

UniProt: P84243
Ensembl: ENST00000254810
Ensembl: ENST00000366813
Ensembl: ENST00000366815
Ensembl: ENST00000366816
Ensembl: ENST00000586607
Ensembl: ENST00000587560
Ensembl: ENST00000589599
MIM: 601058
MIM: 601128
neXtProt: NX_P84243
Antibodypedia: P84243 (may not find the protein thus also not any antibody)
Local full text data: click here

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