HACD3_HUMAN

Source: BSc_CH
PM22954596
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: PTPLAD1 , BIND1, HACD3
Protein names and data: HACD3_HUMAN , Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3; 4.2.1.134 , 3-hydroxyacyl-CoA dehydratase 3; HACD3; Butyrate-induced protein 1; B-ind1; hB-ind1; Protein tyrosine phosphatase-like protein PTPLAD1; Protein-tyrosine phosphatase-like A domain-containing protein 1 Lenght: 362 a.a.
Mass: 43160 Da
fasta formatted sequence
Function: Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression.
Catalytic activity: A very-long-chain (3R)-3-hydroxyacyl-[acyl- carrier protein] = a very-long-chain trans-2,3-dehydroacyl-[acyl- carrier protein] + H(2)O.
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue specificity: Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes.

Genetic variants

Database cross-references

UniProt: Q9P035
Ensembl: ENST00000261875
neXtProt: NX_Q9P035
Antibodypedia: Q9P035 (may not find the protein thus also not any antibody)
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