HACE1_HUMAN

Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: HACE1 , KIAA1320
Protein names and data: HACE1_HUMAN , E3 ubiquitin-protein ligase HACE1; 6.3.2.- , HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 Lenght: 909 a.a.
Mass: 102342 Da
fasta formatted sequence
Function: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
Pathway: Protein modification; protein ubiquitination.
Disease:
Cellular location: Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
Tissue specificity: Expressed in multiple tissues including heart, brain and kidney.

Genetic variants

Database cross-references

UniProt: Q8IYU2
Ensembl: ENST00000262903
Ensembl: ENST00000369125
MIM: 610876
neXtProt: NX_Q8IYU2
Antibodypedia: Q8IYU2 (may not find the protein thus also not any antibody)
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