HDAC6_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: HDAC6 , KIAA0901 , JM21
Protein names and data: HDAC6_HUMAN , Histone deacetylase 6; HD6; 3.5.1.98 Lenght: 1215 a.a.
Mass: 131419 Da
fasta formatted sequence
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
Catalytic activity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Cellular location: Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules.

Genetic variants

Database cross-references

UniProt: Q9UBN7
Ensembl: ENST00000334136
Ensembl: ENST00000376619
Ensembl: ENST00000595349
Ensembl: ENST00000597097
MIM: 300272
neXtProt: NX_Q9UBN7
Antibodypedia: Q9UBN7 (may not find the protein thus also not any antibody)
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