HECD3_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: HECTD3
Protein names and data: HECD3_HUMAN , E3 ubiquitin-protein ligase HECTD3; 6.3.2.- , HECT domain-containing protein 3 Lenght: 861 a.a.
Mass: 97113 Da
fasta formatted sequence
Function: E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).
Pathway: Protein modification; protein ubiquitination.
Cellular location: Cytoplasm, perinuclear region (By similarity).

Database cross-references

UniProt: Q5T447
Ensembl: ENST00000372168
Ensembl: ENST00000372172
neXtProt: NX_Q5T447
Antibodypedia: Q5T447 (may not find the protein thus also not any antibody)
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