HEMGN_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: HEMGN , EDAG, NDR , PRO1037, PRO1620
Protein names and data: HEMGN_HUMAN , Hemogen , Erythroid differentiation-associated gene protein; EDAG-1; Hemopoietic gene protein; Negative differentiation regulator protein Lenght: 484 a.a.
Mass: 55341 Da
fasta formatted sequence
Function: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
Cellular location: Nucleus.
Tissue specificity: Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.

Database cross-references

UniProt: Q9BXL5
Ensembl: ENST00000259456
MIM: 610715
neXtProt: NX_Q9BXL5
Antibodypedia: Q9BXL5 (may not find the protein thus also not any antibody)
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