HEXI1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: HEXIM1 , CLP1, EDG1, HIS1, MAQ1
Protein names and data: HEXI1_HUMAN , Protein HEXIM1 , Cardiac lineage protein 1; Estrogen down-regulated gene 1 protein; Hexamethylene bis-acetamide-inducible protein 1; Menage a quatre protein 1 Lenght: 359 a.a.
Mass: 40623 Da
fasta formatted sequence
Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
Cellular location: Nucleus. Cytoplasm. Note=Binds alpha- importin and is mostly nuclear.
Tissue specificity: Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.

Database cross-references

UniProt: O94992
Ensembl: ENST00000332499
MIM: 607328
neXtProt: NX_O94992
Antibodypedia: O94992 (may not find the protein thus also not any antibody)
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