HNRPK_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: HNRNPK , HNRPK
Protein names and data: HNRPK_HUMAN , Heterogeneous nuclear ribonucleoprotein K; hnRNP K , Transformation up-regulated nuclear protein; TUNP Lenght: 463 a.a.
Mass: 50976 Da
fasta formatted sequence
Function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Cellular location: Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.

Database cross-references

UniProt: P61978
Ensembl: ENST00000351839
Ensembl: ENST00000360384
Ensembl: ENST00000376263
Ensembl: ENST00000376264
Ensembl: ENST00000376281
MIM: 600712
neXtProt: NX_P61978
Antibodypedia: P61978 (may not find the protein thus also not any antibody)
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