HS3S2_HUMAN

Source: hRBCD ; ID: IPI00001856
PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: HS3ST2 , 3OST2 , UNQ2442/PRO5004
Protein names and data: HS3S2_HUMAN , Heparan sulfate glucosamine 3-O-sulfotransferase 2; 2.8.2.29 , Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2; 3-OST-2; Heparan sulfate 3-O-sulfotransferase 2; h3-OST-2 Lenght: 367 a.a.
Mass: 41501 Da
fasta formatted sequence
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
Cellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable).
Tissue specificity: Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle.

Genetic variants

Database cross-references

UniProt: Q9Y278
Ensembl: ENST00000261374
MIM: 604056
neXtProt: NX_Q9Y278
Antibodypedia: Q9Y278 (may not find the protein thus also not any antibody)
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