HSP76_HUMAN
Source:
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence:
low (only semi-automatic identification from reviews)
Search PubMed for
(RBC AND this entry)
Gene names:
HSPA6
, HSP70B'
Protein names and data:
HSP76_HUMAN
, Heat shock 70 kDa protein 6
, Heat shock 70 kDa protein B'
Lenght: 643 a.a.
Mass: 71028 Da
fasta formatted sequence
Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).
Genetic variants
65 - 65
P -> T. VAR_060718
95 - 95
R -> Q. VAR_060719
150 - 150
A -> T (in dbSNP:rs10919224). VAR_049605
10919224
153 - 153
N -> S (in dbSNP:rs10919225). VAR_049606
10919225
154 - 154
D -> N (in dbSNP:rs10919226). VAR_049607
10919226
159 - 159
A -> V. VAR_060720
170 - 170
N -> K (in dbSNP:rs41297704). VAR_049608
41297704
173 - 173
R -> P (in dbSNP:rs41297708). VAR_049609
41297708
178 - 178
P -> A (in dbSNP:rs41297710). VAR_049610
41297710
194 - 194
E -> K (in dbSNP:rs41297714). VAR_049611
41297714
198 - 198
L -> F (in dbSNP:rs1079109). VAR_024182
1079109
260 - 260
R -> H (in dbSNP:rs41299256). VAR_049612
41299256
297 - 297
T -> K. VAR_060721
336 - 336
V -> F (in dbSNP:rs417707). VAR_059360
417707
464 - 464
S -> I (in dbSNP:rs388218). VAR_049613
388218
471 - 471
R -> H (in dbSNP:rs41299256). VAR_049614
41299256
528 - 528
K -> E (in dbSNP:rs570189). VAR_049615
570189
528 - 528
K -> R (in dbSNP:rs570167). VAR_059361
570167
562 - 562
D -> E (in dbSNP:rs753856). VAR_024183
753856
572 - 572
M -> V (in dbSNP:rs452004). VAR_049616
452004
577 - 577
R -> Q (in dbSNP:rs368844). VAR_049617
368844
626 - 626
T -> A (in dbSNP:rs41299260). VAR_049618
41299260
Database cross-references
UniProt:
P17066
Ensembl:
ENST00000309758
MIM:
140555
neXtProt:
NX_P17066
Antibodypedia:
P17066
(may not find the protein thus also not any antibody)
Local full text data:
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