Source: hRBCD ; ID: IPI00003865
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: HSPA8 , HSC70, HSP73, HSPA10
Protein names and data: HSP7C_HUMAN , Heat shock cognate 71 kDa protein , Heat shock 70 kDa protein 8 Lenght: 646 a.a.
Mass: 70898 Da
fasta formatted sequence

Function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.
Cellular location: Cytoplasm. Melanosome. Nucleus, nucleolus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: P11142
Ensembl: ENST00000227378
Ensembl: ENST00000453788
Ensembl: ENST00000532636
Ensembl: ENST00000534624
MIM: 600816
neXtProt: NX_P11142
Antibodypedia: P11142 (may not find the protein thus also not any antibody)
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