HTAI2_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: HTATIP2 , CC3, TIP30
Protein names and data: HTAI2_HUMAN , Oxidoreductase HTATIP2; 1.1.1.- , 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2 Lenght: 242 a.a.
Mass: 27049 Da
fasta formatted sequence
Function: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Cellular location: Cytoplasm. Nucleus envelope.
Tissue specificity: Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.

Genetic variants

Database cross-references

UniProt: Q9BUP3
Ensembl: ENST00000419348
Ensembl: ENST00000421577
Ensembl: ENST00000443524
Ensembl: ENST00000451739
Ensembl: ENST00000530266
Ensembl: ENST00000532081
Ensembl: ENST00000532505
MIM: 605628
neXtProt: NX_Q9BUP3
Antibodypedia: Q9BUP3 (may not find the protein thus also not any antibody)
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