Source: hRBCD ; ID: IPI00000118
BGMUT ; ID: lw
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: ICAM4 , LW
Protein names and data: ICAM4_HUMAN , Intercellular adhesion molecule 4; ICAM-4 , Landsteiner-Wiener blood group glycoprotein; LW blood group protein; CD242; Flags: Precursor Lenght: 271 a.a.
Mass: 29265 Da
fasta formatted sequence

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
Cellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein. Isoform Short: Secreted.
Tissue specificity: Erythrocytes.

Genetic variants

Responsible for the Landsteiner-Wiener blood group system [MIM:111250]. The molecular basis of the LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and Arg-100 to LW(B).

Database cross-references

UniProt: Q14773
Ensembl: ENST00000340992
Ensembl: ENST00000380770
Ensembl: ENST00000393717
MIM: 111250
MIM: 614088
neXtProt: NX_Q14773
Antibodypedia: Q14773 (may not find the protein thus also not any antibody)
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