IDE_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: IDE
Protein names and data: IDE_HUMAN , Insulin-degrading enzyme; 3.4.24.56 , Abeta-degrading protease; Insulin protease; Insulinase; Insulysin Lenght: 1019 a.a.
Mass: 117968 Da
fasta formatted sequence
Function: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
Catalytic activity: Degradation of insulin, glucagon and other polypeptides. No action on proteins.
Cellular location: Cytoplasm. Cell membrane. Secreted (By similarity). Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.

Genetic variants

Database cross-references

UniProt: P14735
Ensembl: ENST00000265986
Ensembl: ENST00000371581
MIM: 146680
neXtProt: NX_P14735
Antibodypedia: P14735 (may not find the protein thus also not any antibody)
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