IF2A_HUMAN

Source: hRBCD ; ID: IPI00219678
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: EIF2S1 , EIF2A
Protein names and data: IF2A_HUMAN , Eukaryotic translation initiation factor 2 subunit 1 , Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha Lenght: 315 a.a.
Mass: 36112 Da
fasta formatted sequence
Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Cellular location: Cytoplasmic granule (By similarity). Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity).

Database cross-references

UniProt: P05198
Ensembl: ENST00000256383
Ensembl: ENST00000466499
MIM: 603907
neXtProt: NX_P05198
Antibodypedia: P05198 (may not find the protein thus also not any antibody)
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