IF2B_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: EIF2S2 , EIF2B
Protein names and data: IF2B_HUMAN , Eukaryotic translation initiation factor 2 subunit 2 , Eukaryotic translation initiation factor 2 subunit beta; eIF-2-beta Lenght: 333 a.a.
Mass: 38388 Da
fasta formatted sequence
Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Genetic variants

Database cross-references

UniProt: P20042
Ensembl: ENST00000374980
MIM: 603908
neXtProt: NX_P20042
Antibodypedia: P20042 (may not find the protein thus also not any antibody)
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