IF5A1_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: EIF5A
Protein names and data: IF5A1_HUMAN , Eukaryotic translation initiation factor 5A-1; eIF-5A-1; eIF-5A1 , Eukaryotic initiation factor 5A isoform 1; eIF-5A; Rev-binding factor; eIF-4D Lenght: 154 a.a.
Mass: 16832 Da
fasta formatted sequence
Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Cellular location: Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
Tissue specificity: Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).

Database cross-references

UniProt: P63241
Ensembl: ENST00000336452
Ensembl: ENST00000336458
Ensembl: ENST00000416016
Ensembl: ENST00000419711
Ensembl: ENST00000571955
Ensembl: ENST00000573542
Ensembl: ENST00000576930
MIM: 600187
neXtProt: NX_P63241
Antibodypedia: P63241 (may not find the protein thus also not any antibody)
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