IF6_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: EIF6 , EIF3A, ITGB4BP , OK/SW-cl.27
Protein names and data: IF6_HUMAN , Eukaryotic translation initiation factor 6; eIF-6 , B(2)GCN homolog; B4 integrin interactor; CAB; p27(BBP) Lenght: 245 a.a.
Mass: 26599 Da
fasta formatted sequence
Function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.
Cellular location: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Tissue specificity: Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).

Database cross-references

UniProt: P56537
Ensembl: ENST00000374436
Ensembl: ENST00000374443
Ensembl: ENST00000374450
MIM: 602912
neXtProt: NX_P56537
Antibodypedia: P56537 (may not find the protein thus also not any antibody)
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