Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: IFIT5 , ISG58, RI58
Protein names and data: IFIT5_HUMAN , Interferon-induced protein with tetratricopeptide repeats 5; IFIT-5 , Interferon-induced 58 kDa protein; Retinoic acid- and interferon-inducible 58 kDa protein; P58 Lenght: 482 a.a.
Mass: 55847 Da
fasta formatted sequence

Function: Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP- RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.
Cellular location: Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.

Database cross-references

UniProt: Q13325
Ensembl: ENST00000371795
neXtProt: NX_Q13325
Antibodypedia: Q13325 (may not find the protein thus also not any antibody)
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