RBCC Red Blood Cell Collection

IGHG3_HUMAN

Source: BSc_CH
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: IGHG3
Protein names and data: IGHG3_HUMAN , Ig gamma-3 chain C region , HDC; Heavy chain disease protein Lenght: 377 a.a.
Mass: 41287 Da
fasta formatted sequence
Cellular location: Secreted.

Genetic variants

The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths. Variant WIS is lacking most of the V region and all of the CH1 region. It has an extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region. Variant ZUC lacks most of the V region, all of the CH1 region, and part of the hinge. Variant OMM may represent an allelic form or another gamma chain subclass.

1 - 76 Missing (in variant WIS). VAR_068695
77 - 98 GTQTYTCNVNHKPSNTKVDKRV -> QMQGVNCTVSS (in variant WIS). VAR_068696
213 - 213 E -> Q (in variant WIS). VAR_068697
214 - 214 V -> B (in variant ZUC). VAR_003890
221 - 221 P -> L (in variant OMM). VAR_003891
224 - 224 E -> Q (in variant WIS). VAR_068698
226 - 226 Y -> F (in variant ZUC and WIS). VAR_003892
242 - 242 D -> N (in variant WIS). VAR_068699
245 - 245 N -> D (in variant WIS). VAR_068700
269 - 269 T -> A (in variant OMM). VAR_003893
314 - 314 S -> N (in variant OMM). VAR_003894
314 - 314 Missing (in variant ZUC). VAR_003895
366 - 366 F -> Y (in variant OMM). VAR_003896

Database cross-references

UniProt: P01860
MIM: 147120
neXtProt: NX_P01860
Antibodypedia: P01860 (may not find the protein thus also not any antibody)
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