IGHM_HUMAN

Source: PM19886704
PM23856902
BSc_CH
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: IGHM
Protein names and data: IGHM_HUMAN , Ig mu chain C region Lenght: 452 a.a.
Mass: 49307 Da
fasta formatted sequence
Function: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
Disease:
Cellular location: Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM. Isoform 2: Cell membrane; Single-pass type I membrane protein.

Genetic variants

All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 215 have been observed in human mu chains.

Database cross-references

UniProt: P01871
MIM: 147020
MIM: 601495
neXtProt: NX_P01871
Antibodypedia: P01871 (may not find the protein thus also not any antibody)
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