IKBB_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NFKBIB , IKBB, TRIP9
Protein names and data: IKBB_HUMAN , NF-kappa-B inhibitor beta; NF-kappa-BIB , I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9 Lenght: 356 a.a.
Mass: 37771 Da
fasta formatted sequence
Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Cellular location: Cytoplasm (By similarity). Nucleus (By similarity).
Tissue specificity: Expressed in all tissues examined.

Genetic variants

Database cross-references

UniProt: Q15653
Ensembl: ENST00000313582
Ensembl: ENST00000572515
MIM: 604495
neXtProt: NX_Q15653
Antibodypedia: Q15653 (may not find the protein thus also not any antibody)
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