RBCC

IKKE_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: IKBKE , IKKE, IKKI, KIAA0151
Protein names and data: IKKE_HUMAN , Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; 2.7.11.10 , Inducible I kappa-B kinase; IKK-i Lenght: 716 a.a.
Mass: 80462 Da
fasta formatted sequence
Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage- induced cell death.
Catalytic activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
Cellular location: Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS- dependent.
Tissue specificity: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.

Genetic variants

128 - 128 E -> K (in dbSNP:rs41296028). VAR_038816 41296028
371 - 371 A -> T (in dbSNP:rs17021877). VAR_038817 17021877
483 - 483 T -> M (in dbSNP:rs52817862). VAR_040571 52817862
515 - 515 E -> D (in dbSNP:rs41299015). VAR_038818 41299015
543 - 543 I -> M (in dbSNP:rs41299037). VAR_038819 41299037
602 - 602 A -> V (in dbSNP:rs12059562). VAR_038820 12059562
660 - 660 G -> E (in dbSNP:rs55822317). VAR_040572 55822317
713 - 713 P -> L (in dbSNP:rs3748022). VAR_019989 3748022

Database cross-references

UniProt: Q14164
Ensembl: ENST00000367120
Ensembl: ENST00000537984
Ensembl: ENST00000581977
Ensembl: ENST00000584998
MIM: 605048
neXtProt: NX_Q14164
Antibodypedia: Q14164 (may not find the protein thus also not any antibody)
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RBCC Red Blood Cell Collection

IKKE_HUMAN

Genetic variants

Database cross-references

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