Source: BD_CD
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: IL1R1 , IL1R, IL1RA, IL1RT1
Protein names and data: IL1R1_HUMAN , Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1 , CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD121a; Interleukin-1 receptor type 1, membrane form; mIL-1R1; mIL-1RI; Interleukin-1 receptor type 1, soluble form; sIL-1R1; sIL-1RI; Flags: Precursor Lenght: 569 a.a.
Mass: 65402 Da
fasta formatted sequence

Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
Cellular location: Membrane; Single-pass type I membrane protein. Cell membrane (Probable). Secreted.

Genetic variants

Database cross-references

UniProt: P14778
Ensembl: ENST00000233946
Ensembl: ENST00000410023
MIM: 147810
neXtProt: NX_P14778
Antibodypedia: P14778 (may not find the protein thus also not any antibody)
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