Source: BD_CD
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: IL1R2 , IL1RB
Protein names and data: IL1R2_HUMAN , Interleukin-1 receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2 , CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II; CD121b; Interleukin-1 receptor type 2, membrane form; mIL-1R2; mIL-1RII; Interleukin-1 receptor type 2, soluble form; sIL-1R2; sIL-1RII; Flags: Precursor Lenght: 398 a.a.
Mass: 45421 Da
fasta formatted sequence

Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Cellular location: Isoform Short: Secreted. Isoform Long: Cell membrane; Single-pass type I membrane protein.

Genetic variants

Database cross-references

UniProt: P27930
Ensembl: ENST00000332549
Ensembl: ENST00000393414
Ensembl: ENST00000441002
MIM: 147811
neXtProt: NX_P27930
Antibodypedia: P27930 (may not find the protein thus also not any antibody)
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