Source: BD_CD
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: IL6R
Protein names and data: IL6RA_HUMAN , Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA , IL-6R 1; Membrane glycoprotein 80; gp80; CD126; Flags: Precursor Lenght: 468 a.a.
Mass: 51548 Da
fasta formatted sequence

Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
Cellular location: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

Genetic variants

Genetic variations in IL6R determine soluble IL6R serum levels [MIM:614689]. Genetic variations in IL6R define the IL6 serum level quantitative trait locus [MIM:614752].

Database cross-references

UniProt: P08887
Ensembl: ENST00000344086
Ensembl: ENST00000368485
MIM: 147880
MIM: 614689
MIM: 614752
neXtProt: NX_P08887
Antibodypedia: P08887 (may not find the protein thus also not any antibody)
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