Source: BD_CD
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: IL6ST
Protein names and data: IL6RB_HUMAN , Interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB , CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD130; Flags: Precursor Lenght: 918 a.a.
Mass: 103537 Da
fasta formatted sequence

Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
Tissue specificity: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.

Genetic variants

Database cross-references

UniProt: P40189
Ensembl: ENST00000336909
Ensembl: ENST00000381287
Ensembl: ENST00000381294
Ensembl: ENST00000381298
Ensembl: ENST00000502326
Ensembl: ENST00000522633
Ensembl: ENST00000536319
MIM: 600694
neXtProt: NX_P40189
Antibodypedia: P40189 (may not find the protein thus also not any antibody)
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