ILF3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ILF3 , DRBF, MPHOSPH4, NF90
Protein names and data: ILF3_HUMAN , Interleukin enhancer-binding factor 3 , Double-stranded RNA-binding protein 76; DRBP76; M-phase phosphoprotein 4; MPP4; Nuclear factor associated with dsRNA; NFAR; Nuclear factor of activated T-cells 90 kDa; NF-AT-90; Translational control protein 80; TCP80 Lenght: 894 a.a.
Mass: 95338 Da
fasta formatted sequence
Function: May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N- methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).
Cellular location: Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q12906
Ensembl: ENST00000250241
Ensembl: ENST00000318511
Ensembl: ENST00000407004
Ensembl: ENST00000420083
Ensembl: ENST00000449870
Ensembl: ENST00000588657
Ensembl: ENST00000589998
Ensembl: ENST00000590261
Ensembl: ENST00000592763
MIM: 603182
neXtProt: NX_Q12906
Antibodypedia: Q12906 (may not find the protein thus also not any antibody)
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