IMA1_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: KPNA2 , RCH1, SRP1
Protein names and data: IMA1_HUMAN , Importin subunit alpha-1 , Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha Lenght: 529 a.a.
Mass: 57862 Da
fasta formatted sequence
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Expressed ubiquitously.

Genetic variants

Database cross-references

UniProt: P52292
Ensembl: ENST00000330459
Ensembl: ENST00000537025
Ensembl: ENST00000571293
Ensembl: ENST00000574083
MIM: 600685
neXtProt: NX_P52292
Antibodypedia: P52292 (may not find the protein thus also not any antibody)
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