IMA3_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: KPNA4 , QIP1
Protein names and data: IMA3_HUMAN , Importin subunit alpha-3 , Importin alpha Q1; Qip1; Karyopherin subunit alpha-4 Lenght: 521 a.a.
Mass: 57887 Da
fasta formatted sequence
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Cellular location: Cytoplasm (By similarity). Nucleus (By similarity).
Tissue specificity: Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.

Database cross-references

UniProt: O00629
Ensembl: ENST00000334256
MIM: 602970
neXtProt: NX_O00629
Antibodypedia: O00629 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.